function runtimeParameterTuning()
simMode = 'rapid';
model = 'example_modify_parameters';
ref = 'exRefModelWorkspaceVars';
load_system(model);
closeModels = onCleanup(@() cellfun(@(x)close_system(x,0),{model,ref}));
set_param(model, "SimulationMode", simMode);

% Get simulation input object
simInput = Simulink.SimulationInput(model);
% Set post-step callback function that tunes variables
simInput = simulink.compiler.setPostStepFcn(simInput,@(time)postStepParameterTuner(time,model));

out = sim(simInput);
end

function postStepParameterTuner(time,model)
% Callback which tunes parameters based on time
if time==5.0
    % Modify global variables used by top model gain block
    newGlobalVars = [Simulink.Simulation.Variable('gNum',1.1),...
                     Simulink.Simulation.Variable('gDen',0.5)];
    simulink.compiler.modifyParameters(model,newGlobalVars);
end
if time==2.5
    % Modify variables in reference model workspace
    newRefWksVars = [Simulink.Simulation.Variable('gNum',1.2),...
                     Simulink.Simulation.Variable('gDen',0.1)];
    simulink.compiler.modifyParameters(model,newRefWksVars);
end
if time==4.5
    % Modify variables used by mask dialog parameters
    newMaskVars = [Simulink.Simulation.Variable('mGain',2.0),...
                   Simulink.Simulation.Variable('Bias',-1,'Workspace',model)];
    simulink.compiler.modifyParameters(model,newMaskVars);
end
end